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Secondly Buprenorphine is a derivative of the opioid alkaloid the baine that is a more potent (25 – 40 times) and longer lasting analgesic than morphine.
Hence It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. So The lack of delta-agonist activity has been suggest to account. For the observation that buprenorphine tolerance may not develop with chronic use.