Buy Melanotan 2 (Melanotan) 10MG
To begin with Buy Melanotan 2 (Melanotan) 10MG Online. Melanotan-1 Peptide Amino Acid Sequence:
Molecular formula: C78H111N21O19
Molar Mass: 1646.845
CAS number: 75921-69-6
Synonyms: Melanotan; Melanotan-1; Melanotan I; CUV1647; EPT1647; NDP-MSH; [Nle4, D-Phe7]α-MSH
[Nle4, D-Phe7]-α-MSH Melanotan
Secondly Melanotan 2 (also referred to as Afamelanotide) is a synthetic peptide variant of a peptide hormone. called alpha-Melanocyte stimulating hormone or MSH that is naturally produced in the body and is responsible for stimulating melanogenesis. a peptide process for pigmentation of the skin.
Therefor Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects.
Hence , MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors.
More so As a result, Melanotan-1 sunless skin tanning effects. While Melanotan 2 and PT-141 have been studied at length as a potential remedies for the treatment of sexual dysfunction. Melanotan-1 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.
Both Melanotan-1 and Melanotan 2 are analogs of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that tend to induce skin tanning.
Unlike Melanotan 1, Melanotan 2 has been shown to have aphrodisiac properties, the additional effect of increasing libido. Melanotan-1 is a non selective agonist of the melanocortin receptors (MC1R,MC3-5R). As an analogue of α-MSH, its mechanism of action is biomimicry of the natural mammalian tanning process.
Melanotan-1 How it Works!
Melanotan produces its photoprotective effects by triggering a ‘signaling cascade’ via its activation of the MC1R on melanin-producing cells known as melanocytes.
In addition Upon Melanotan binding with the MC1R on the surface of melanocytes in the epidermal layer of the skin. it begins a series of actions and reactions that result in melanocytes favoring the production of eumelanin (photoprotective black/brown pigment).
The initial binding activates the MC1R leading to the activation of adenylate cyclase (AC) and stimulation of the production of cyclic adenosine monophosphate (cAMP).
Furthermore CAMP in turn activates protein kinase A (PKA) resulting in the phosphorylation of the cAMP response element-binding (CREB). Phosphorylated CREB will bind to the cAMP response element (CRE) on the microphthalmia-associated transcription factor (MITF) gene leading to the synthesis of the MITF protein.
MITF has the ability to activate several genes by binding to them, including the MC1R gene and the genes involved in melanogenesis. This results in increased concentrations of the melanogenic enzymes within the melanocyte.
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