Epithalon (Epitalon) 50mg
Firstly Buy Epithalon (Epitalon) 50mg. Epithalon Tetra Peptide Sequence: alanyl-glutamyl-aspartyl-glycine
Molecular Formula: C14H22N4O9
Molecular Weight: 390.34588
Epitalon Tetra Peptide
Epithalon is a peptide use to regulate the cell cycle through up-regulation of telomerase activity. The sequence of amino acids in the peptide is Alanine-Glutamate-Asparagine-Glycine. Animal studies have been done on the effects of Epithalon on suppression of spontaneous mammary tumors and spontaneous carcinogenesis. Studies have shown that the mode of action of Epithalon involves suppression of oncogene expression and modification of telomerase activity. A summary of the studies and research on telomerase is provided below.
Telomerase is a specific RNA (ribonucleic acid)-dependent polymerase that elongates and maintains the length of telomeres by adding tandem repeats on the chromosomal 3′ end. The enzyme is compose of two parts: an RNA component which supplies the telomere template for elongation, and the catalytic subunit which possesses reverse transcriptase activity. These two parts work in tandem to avert telomere attrition especially in somatic cells. Buy Epithalon (Epitalon) 50mg online
In vitro experiments have shown that telomere elongation promotes indefinite cellular proliferation and that suppression of telomerase activity promotes apoptosis of neoplastic cells. However, these studies have also shown that maintenance of telomere length within a range of 15-20 kilobase pairs does prevent tumorigenesis. All the research and studies done concerning telomerase do show that telomerase activity is limite to cell division through its action of stabilizing the telomere length.
Telomeres are located at either ends of a chromosome, and they do protect the adjacent gene sequence from shortening due to repeated replication cycles. Elongation of telomeres enables senescent cells to stabilize their telomeric length. However, excess elongation would enable such cells to exceed their Hayflick limit via evasion of apoptosis or the post-mitotic phase; and therefore, such cells have the potential of becoming immortal and this predisposes them to neoplastic transformation.
Human telomeres are made up of tandem repeats of the nucleotide sequence TTAGGG that form a T loop structure when associated with telomere-binding proteins.
The T loop structure ensures the integrity of the telomeres by protecting them from constitutive degradation. These tandem repeats do shorten as a consequence of repeate chromosomal replication cycles. Such shortening is due to the inability of DNA polymerase to repeatedly replicate the nucleotides locate in the T loop region. This leads to senescence or growth arrest, and a critically shorten telomere does induce a p53-mediate DNA checkpoint reaction.
Some cells do evade senescence if they have nonfunctional p53 and/or pRb, but cell death still occurs due to either lethal DNA rearrangements or chromosomal fusion. Thus, evasion of telomere-mediated senescence is the main way that cells use to avert premature senescence and apoptosis. This occurs only when telomerase activity is up-regulate.
Telomerase elongation leads to stabilization of the genotype as the rate of gene mutation is maintain within normal limits. However, an increase in the rate of apoptosis leads to a proportionate increase in cellular regeneration rate, and this causes an increase in the number of sporadic gene mutations that occur thus predisposing the person to pro-neoplastic mutations.
Current studies show that telomere shortening is associate with chronic diseases such as pulmonary fibrosis, coronary artery disease, diabetes mellitus and Alzheimer’s disease, though their findings are still consider inconclusive. Base on the findings of these studies, it can be theorize that Epithalon could prevent the development of these diseases.
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